While I'm always of the opinion that "there's no such thing as bad characters, just bad writers" and I'm aware that a late-90s live action television production wasn't doing her any favors, I think Venus would have a lot of serious hurdles to get over before anyone would be willing to accept her.
She's loaded with a lot of baggage; being the avatar of everything that was wrong with Next Mutation, even though that show had problems that went weeellllll beyond the female turtle.
Even though there's always the potential to make her work via a serious character overhaul, I just think her reputation among fans ensures that chance will never come.
Personally, I'm willing to give every goofy character a second chance, and lord knows the TMNT universe is STOCKED with goofy characters, but Venus would be a pretty big uphill battle.
And ditto on the plastron breasts. Even ignoring the whole cold-blooded, egg-laying reptile thing, the plastron breasts just looked stupid. I've seen some fanart that makes her look suitably feminine without giving her a pronounced chest or sending her into disgusting "Rule 34" territory, so it's not like it's a dealbreaker.